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The release of inhibition model reproduces kinetics and plasticity of neurotransmitter release in central synapses

Calcium-evoked release of neurotransmitters from synaptic vesicles (SVs) is catalysed by SNARE proteins. The predominant view is that, at rest, complete assembly of SNARE complexes is inhibited (‘clamped’) by synaptotagmin and complexin molecules. Calcium binding by synaptotagmins releases this fusi...

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Detalles Bibliográficos
Autores principales: Norman, Christopher A, Krishnakumar, Shyam S, Timofeeva, Yulia, Volynski, Kirill E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168444/
https://www.ncbi.nlm.nih.gov/pubmed/37163032
http://dx.doi.org/10.21203/rs.3.rs-2700789/v1