Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands

[Image: see text] The design of dualsteric/bitopic agents as single chemical entities able to simultaneously interact with both the orthosteric and an allosteric binding site represents a novel approach in medicinal chemistry. Biased dualsteric/bitopic agents could enhance certain signaling pathways...

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Detalles Bibliográficos
Autores principales: Gado, Francesca, Ferrisi, Rebecca, Polini, Beatrice, Mohamed, Kawthar A., Ricardi, Caterina, Lucarini, Elena, Carpi, Sara, Domenichini, Federica, Stevenson, Lesley A., Rapposelli, Simona, Saccomanni, Giuseppe, Nieri, Paola, Ortore, Gabriella, Pertwee, Roger G., Ghelardini, Carla, Di Cesare Mannelli, Lorenzo, Chiellini, Grazia, Laprairie, Robert B., Manera, Clementina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168668/
https://www.ncbi.nlm.nih.gov/pubmed/35849804
http://dx.doi.org/10.1021/acs.jmedchem.2c00582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168668/
https://www.ncbi.nlm.nih.gov/pubmed/35849804
http://dx.doi.org/10.1021/acs.jmedchem.2c00582

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