Clonal architecture evolution in Myeloproliferative Neoplasms: from a driver mutation to a complex heterogeneous mutational and phenotypic landscape

Myeloproliferative neoplasms are characterized by the acquisition at the hematopoietic stem cell level of driver mutations targeting the JAK/STAT pathway. In addition, they also often exhibit additional mutations targeting various pathways such as intracellular signalling, epigenetics, mRNA splicing...

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Detalles Bibliográficos
Autores principales: Maslah, Nabih, Benajiba, Lina, Giraudier, Stephane, Kiladjian, Jean-Jacques, Cassinat, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169637/
https://www.ncbi.nlm.nih.gov/pubmed/37002477
http://dx.doi.org/10.1038/s41375-023-01886-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169637/
https://www.ncbi.nlm.nih.gov/pubmed/37002477
http://dx.doi.org/10.1038/s41375-023-01886-0

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