A frequent SNP in TRIM5α strongly enhances the innate immune response against LINE-1 elements

The intracellular restriction factor TRIM5α inhibits endogenous LINE-1 retroelements. It induces innate immune signaling cascades upon sensing of cytoplasmic LINE-1 complexes, thereby underlining its importance for protecting the human genome from harmful retrotransposition events. Here, we show tha...

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Detalles Bibliográficos
Autores principales: Lagisquet, Justine, Conrad, Marcus, Wittmann, Sabine, Volkmann, Bianca, Weissinger, Hannah, Sticht, Heinrich, Gramberg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169663/
https://www.ncbi.nlm.nih.gov/pubmed/37180175
http://dx.doi.org/10.3389/fimmu.2023.1168589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169663/
https://www.ncbi.nlm.nih.gov/pubmed/37180175
http://dx.doi.org/10.3389/fimmu.2023.1168589

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