Cargando…

In situ continuous Dopa supply by responsive artificial enzyme for the treatment of Parkinson’s disease

Oral dihydroxyphenylalanine (Dopa) administration to replenish neuronal dopamine remains the most effective treatment for Parkinson’s disease (PD). However, unlike the continuous and steady dopamine signaling in normal neurons, oral Dopa induces dramatic fluctuations in plasma Dopa levels, leading t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fang, Xiao, Yuan, Meng, Zhao, Fang, Yu, Aoling, Lin, Qianying, Li, Shiqing, Li, Huichen, Wang, Xinyang, Yu, Yanbin, Wang, Xin, Lin, Qitian, Lu, Chunhua, Yang, Huanghao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169781/ https://www.ncbi.nlm.nih.gov/pubmed/37160866 http://dx.doi.org/10.1038/s41467-023-38323-w

Ejemplares similares

Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease
por: Cederfjäll, Erik, et al.
Publicado: (2013)

Differences in Brain Activity Between Dopa-Responsive and -Unresponsive Pain in Parkinson’s Disease
por: Zheng, Jin Hua, et al.
Publicado: (2022)

Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota
por: Wang, Yan, et al.
Publicado: (2021)

Identification of TH Variants in Chinese Dopa-Responsive Dystonia Patients and Long-Term Outcomes
por: Li, Xin-yao, et al.
Publicado: (2021)

L-DOPA
por: Hornykiewicz, Oleh
Publicado: (2017)

Genetic Diagnosis of Two Dopa-Responsive Dystonia Families by Exome Sequencing
por: Sun, Zhan-fang, et al.
Publicado: (2014)

L-DOPA-therapy in Parkinson’s disease: some personal reflections on L-DOPA therapy from Vienna and Berlin
por: Riederer, Peter, et al.
Publicado: (2023)

Polymorphism of the Dopa-Decarboxylase Gene Modifies the Motor Response to Levodopa in Chinese Patients With Parkinson's Disease
por: Li, Lanting, et al.
Publicado: (2020)

Dopa Responsive Slow Orthostatic Tremor in Parkinson’s Disease
por: Lee, Suk Yoon, et al.
Publicado: (2011)

Molecular Effects of L-dopa Therapy in Parkinson’s Disease
por: Dorszewska, Jolanta, et al.
Publicado: (2014)

Beyond L-DOPA: hope for Parkinson’s treatment and diagnosis
Publicado: (2017)

Predictors of Levo-dopa induced Dyskinesias in Parkinson's Disease
por: Athulya, RT, et al.
Publicado: (2020)

L-Dopa and Behavior
por: Kebabian, John
Publicado: (1974)

Revisiting the L-Dopa Response as a Predictor of Motor Outcomes After Deep Brain Stimulation in Parkinson’s Disease
por: Lin, Zhengyu, et al.
Publicado: (2021)

Parkinson’s disease, L-DOPA, and endogenous morphine: A revisit
por: Stefano, George B., et al.
Publicado: (2012)

DOPA-sparing strategy in the treatment of young onset Parkinson's disease
por: Rana, Abdul Qayyum, et al.
Publicado: (2016)

L-DOPA in Parkinson’s Disease: Looking at the “False” Neurotransmitters and Their Meaning
por: Chagraoui, Abdeslam, et al.
Publicado: (2019)

Achieving Continuous Self‐Powered Energy Conversion‐Storage‐Supply Integrated System Based on Carbon Felt
por: Peiyuan, Ji, et al.
Publicado: (2023)

Inhaling xenon ameliorates l‐dopa‐induced dyskinesia in experimental parkinsonism
por: Baufreton, Jérôme, et al.
Publicado: (2018)

An Integrative Approach to Treat Parkinson's Disease: Ukgansan Complements L-Dopa by Ameliorating Dopaminergic Neuronal Damage and L-Dopa-Induced Dyskinesia in Mice
por: Huh, Eugene, et al.
Publicado: (2019)

Novel anti-apoptotic L-DOPA precursors SuperDopa and SuperDopamide as potential neuroprotective agents for halting/delaying progression of Parkinson’s disease
por: Wiesen, Tom, et al.
Publicado: (2022)

The Effect of Aminopterin on the Autoxidation of Dopa
por: Lea, A. J.
Publicado: (1951)

L-Dopa and the Albino Riddle: Content of L-Dopa in the Developing Retina of Pigmented and Albino Mice
por: Roffler-Tarlov, Suzanne, et al.
Publicado: (2013)

Is DOPA-Responsive Hypokinesia Responsible for Bimanual Coordination Deficits in Parkinson’s Disease?
por: Almeida, Quincy J., et al.
Publicado: (2013)

Altered cerebellar connectivity in Parkinson's patients ON and OFF L-DOPA medication
por: Festini, Sara B., et al.
Publicado: (2015)

Novel GCH1 variant in Dopa-responsive dystonia and Parkinson's disease
por: Lewthwaite, A.J., et al.
Publicado: (2015)

Orbitofrontal (18)F-DOPA Uptake and Movement Preparation in Parkinson's Disease
por: Marinelli, Lucio, et al.
Publicado: (2015)

The Design and Evaluation of an l-Dopa–Lazabemide Prodrug for the Treatment of Parkinson’s Disease
por: Hoon, Monique, et al.
Publicado: (2017)

Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson’s Disease
por: Bello, Fabio Del, et al.
Publicado: (2019)

L-DOPA Neurotoxicity Is Mediated by Up-Regulation of DMT1−IRE Expression
por: Du, Fang, et al.
Publicado: (2009)

L-dopa treatment increases oscillatory power in the motor cortex of Parkinson's disease patients
por: Cao, Chunyan, et al.
Publicado: (2020)

Atypical presentation of dopa‐responsive dystonia in Taiwan
por: Weng, Yi Ching, et al.
Publicado: (2018)

Molecular design principles of Lysine-DOPA wet adhesion
por: Li, Yiran, et al.
Publicado: (2020)

Statistically optimized biotransformation protocol for continuous production of L-DOPA using Mucuna monosperma callus culture
por: Inamdar, Shrirang Appasaheb, et al.
Publicado: (2013)

Betalain production is possible in anthocyanin-producing plant species given the presence of DOPA-dioxygenase and L-DOPA
por: Harris, Nilangani N, et al.
Publicado: (2012)

Interaction of Human Dopa Decarboxylase with L-Dopa: Spectroscopic and Kinetic Studies as a Function of pH
por: Montioli, Riccardo, et al.
Publicado: (2013)

Therapeutic Effect of Hydrogen Sulfide-Releasing L-Dopa Derivative ACS84 on 6-OHDA-Induced Parkinson’s Disease Rat Model
por: Xie, Li, et al.
Publicado: (2013)

Inhibition of Glycogen Synthase Kinase-3β (GSK-3β) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats
por: Xie, Cheng-long, et al.
Publicado: (2016)

Investigations of brain-wide functional and structural networks of dopaminergic and CamKIIα-positive neurons in VTA with DREADD-fMRI and neurotropic virus tracing technologies
por: Zheng, Ning, et al.
Publicado: (2023)

Maladaptive Synaptic Plasticity in L-DOPA-Induced Dyskinesia
por: Wang, Qiang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mfaju9090dl11o8a1blkd14duj