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Autocitrullination confers monocyte chemotactic properties to peptidylarginine deiminase 4

Peptidylarginine deiminase 4 (PAD4) contributes to the production of citrullinated proteins as autoantigens for anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA). PAD4 can also self-deiminate via autocitrullination. However, the role of this process in RA pathogenesis has no...

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Detalles Bibliográficos
Autores principales: Yoshida, Ken, Ito, Haruyasu, Kurosaka, Daisaburo, Ikeda, Ryo, Noda, Kentaro, Saito, Mitsuru, Kurosaka, Daitaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169855/
https://www.ncbi.nlm.nih.gov/pubmed/37160933
http://dx.doi.org/10.1038/s41598-023-34469-1