Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein

Calcium-selective oncochannel TRPV6 is the major driver of cell proliferation in human cancers. While significant effort has been invested in the development of synthetic TRPV6 inhibitors, natural channel blockers have been largely neglected. Here we report the structure of human TRPV6 in complex wi...

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Detalles Bibliográficos
Autores principales: Neuberger, Arthur, Trofimov, Yury A., Yelshanskaya, Maria V., Nadezhdin, Kirill D., Krylov, Nikolay A., Efremov, Roman G., Sobolevsky, Alexander I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169861/
https://www.ncbi.nlm.nih.gov/pubmed/37160865
http://dx.doi.org/10.1038/s41467-023-38352-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169861/
https://www.ncbi.nlm.nih.gov/pubmed/37160865
http://dx.doi.org/10.1038/s41467-023-38352-5

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