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Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein
Calcium-selective oncochannel TRPV6 is the major driver of cell proliferation in human cancers. While significant effort has been invested in the development of synthetic TRPV6 inhibitors, natural channel blockers have been largely neglected. Here we report the structure of human TRPV6 in complex wi...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169861/ https://www.ncbi.nlm.nih.gov/pubmed/37160865 http://dx.doi.org/10.1038/s41467-023-38352-5 |