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Lysine deserts prevent adventitious ubiquitylation of ubiquitin-proteasome components
In terms of its relative frequency, lysine is a common amino acid in the human proteome. However, by bioinformatics we find hundreds of proteins that contain long and evolutionarily conserved stretches completely devoid of lysine residues. These so-called lysine deserts show a high prevalence in int...
Autores principales: | Kampmeyer, Caroline, Grønbæk-Thygesen, Martin, Oelerich, Nicole, Tatham, Michael H., Cagiada, Matteo, Lindorff-Larsen, Kresten, Boomsma, Wouter, Hofmann, Kay, Hartmann-Petersen, Rasmus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169902/ https://www.ncbi.nlm.nih.gov/pubmed/37160462 http://dx.doi.org/10.1007/s00018-023-04782-z |
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