Canonical and truncated transglutaminase-2 regulate mucin-1 expression and androgen independency in prostate cancer cell lines

Androgen independency is associated with poor prostate cancer (PCa) survival. Here we report that silencing of transglutaminase-2 (TG2) expression by CRISPR-Cas9 is associated with upregulation of androgen receptor (AR) transcription in PCa cell lines. Knockout of TG2 reversed the migratory potentia...

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Detalles Bibliográficos
Autores principales: Atobatele, Adeola Grace, Tonoli, Elisa, Vadakekolathu, Jayakumar, Savoca, Maria Pia, Barr, Melissa, Kataria, Yukti, Rossanese, Marta, Burhan, Izhar, McArdle, Stephanie, Caccamo, Daniela, Verderio, Elisabetta A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170068/
https://www.ncbi.nlm.nih.gov/pubmed/37160910
http://dx.doi.org/10.1038/s41419-023-05818-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170068/
https://www.ncbi.nlm.nih.gov/pubmed/37160910
http://dx.doi.org/10.1038/s41419-023-05818-9

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