TFEB inhibition induces melanoma shut-down by blocking the cell cycle and rewiring metabolism

Melanomas are characterised by accelerated cell proliferation and metabolic reprogramming resulting from the contemporary dysregulation of the MAPK pathway, glycolysis and the tricarboxylic acid (TCA) cycle. Here, we suggest that the oncogenic transcription factor EB (TFEB), a key regulator of lysos...

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Detalles Bibliográficos
Autores principales: Ariano, C., Costanza, F., Akman, M., Riganti, C., Corà, D., Casanova, E., Astanina, E., Comunanza, V., Bussolino, F., Doronzo, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170071/
https://www.ncbi.nlm.nih.gov/pubmed/37160873
http://dx.doi.org/10.1038/s41419-023-05828-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170071/
https://www.ncbi.nlm.nih.gov/pubmed/37160873
http://dx.doi.org/10.1038/s41419-023-05828-7

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