Anti-human-TIGIT agonistic antibody ameliorates autoimmune diseases by inhibiting Tfh and Tph cells and enhancing Treg cells

T cells play important roles in autoimmune diseases, but it remains unclear how to optimally manipulate them. We focused on the T cell immunoreceptor with Ig and ITIM domains (TIGIT), a coinhibitory molecule that regulates and is expressed in T cells. In autoimmune diseases, the association between...

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Detalles Bibliográficos
Autores principales: Kojima, Marenori, Suzuki, Katsuya, Takeshita, Masaru, Ohyagi, Masaki, Iizuka, Mana, Yamane, Humitsugu, Koga, Keiko, Kouro, Taku, Kassai, Yoshiaki, Yoshihara, Tomoki, Adachi, Ryutaro, Hashikami, Kentarou, Ota, Yuichiro, Yoshimoto, Keiko, Kaneko, Yuko, Morita, Rimpei, Yoshimura, Akihiko, Takeuchi, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170076/
https://www.ncbi.nlm.nih.gov/pubmed/37161050
http://dx.doi.org/10.1038/s42003-023-04874-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170076/
https://www.ncbi.nlm.nih.gov/pubmed/37161050
http://dx.doi.org/10.1038/s42003-023-04874-3

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