MGMT is frequently inactivated in pancreatic NET-G2 and is associated with the therapeutic activity of STZ-based regimens

O6-methylguanine-DNA methyltransferase (MGMT) has been linked with alkylating agent resistance and tumor growth suppression. However, its role remains undetermined in pancreatic neuroendocrine tumors (Pan-NET). The MGMT expression was examined by immunohistochemistry in 142 patients to evaluate MGMT...

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Detalles Bibliográficos
Autores principales: Yagi, Kohei, Ono, Hiroaki, Kudo, Atsushi, Kinowaki, Yuko, Asano, Daisuke, Watanabe, Shuichi, Ishikawa, Yoshiya, Ueda, Hiroki, Akahoshi, Keiichi, Tanaka, Shinji, Tanabe, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170117/
https://www.ncbi.nlm.nih.gov/pubmed/37161026
http://dx.doi.org/10.1038/s41598-023-34666-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170117/
https://www.ncbi.nlm.nih.gov/pubmed/37161026
http://dx.doi.org/10.1038/s41598-023-34666-y

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