Selective Non-toxics Inhibitors Targeting DHFR for Tuberculosis and Cancer Therapy: Pharmacophore Generation and Molecular Dynamics Simulation

Dihydrofolate reductase (DHFR) is a crucial enzyme that catalyzes the conversion of folic acid. Its reserved properties and significance in both human (h-DHFR) and mycobacterium (mt-DHFR) make it a challenging target for developing drugs against cancer and bacterial infections. Although methotrexate...

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Detalles Bibliográficos
Autores principales: Haddoumi, Ghyzlane EL, Mansouri, Mariam, Bendani, Houda, Chemao-Elfihri, Mohammed Walid, Kourou, Jouhaina, Abbou, Hanane, Belyamani, Lahcen, Kandoussi, Ilham, Ibrahimi, Azeddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170603/
https://www.ncbi.nlm.nih.gov/pubmed/37180813
http://dx.doi.org/10.1177/11779322231171778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170603/
https://www.ncbi.nlm.nih.gov/pubmed/37180813
http://dx.doi.org/10.1177/11779322231171778

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