Cyp4a12-mediated retinol metabolism in stellate cells is the antihepatic fibrosis mechanism of the Chinese medicine Fuzheng Huayu recipe

BACKGROUND: Hepatic stellate cells (HSCs), which contain multiple retinol-containing lipid droplets, are important profibrotic cells in liver fibrosis. Under Cyp4a12a/b oxidation, HSC activation was accompanied by the downregulation of genes involved in retinol metabolism, inducing RAE-1 production....

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Detalles Bibliográficos
Autores principales: Ping, Da-bing, Sun, Xin, Peng, Yuan, Liu, Cheng-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170698/
https://www.ncbi.nlm.nih.gov/pubmed/37161575
http://dx.doi.org/10.1186/s13020-023-00754-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170698/
https://www.ncbi.nlm.nih.gov/pubmed/37161575
http://dx.doi.org/10.1186/s13020-023-00754-4

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