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The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes
BACKGROUND: Proteolysis of the histone H3 N-terminal tail (H3NT) is an evolutionarily conserved epigenomic feature of nearly all eukaryotes, generating a cleaved H3 product that is retained in ~ 5–10% of the genome. Although H3NT proteolysis within chromatin was first reported over 60 years ago, the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170761/ https://www.ncbi.nlm.nih.gov/pubmed/37161413 http://dx.doi.org/10.1186/s13072-023-00491-w |