Dodecamer assembly of a metazoan AAA(+) chaperone couples substrate extraction to refolding

Ring-forming AAA(+) chaperones solubilize protein aggregates and protect organisms from proteostatic stress. In metazoans, the AAA(+) chaperone Skd3 in the mitochondrial intermembrane space (IMS) is critical for human health and efficiently refolds aggregated proteins, but its underlying mechanism i...

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Detalles Bibliográficos
Autores principales: Gupta, Arpit, Lentzsch, Alfred M., Siegel, Alex, Yu, Zanlin, Chio, Un Seng, Cheng, Yifan, Shan, Shu-ou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171807/
https://www.ncbi.nlm.nih.gov/pubmed/37163603
http://dx.doi.org/10.1126/sciadv.adf5336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171807/
https://www.ncbi.nlm.nih.gov/pubmed/37163603
http://dx.doi.org/10.1126/sciadv.adf5336

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