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Dodecamer assembly of a metazoan AAA(+) chaperone couples substrate extraction to refolding
Ring-forming AAA(+) chaperones solubilize protein aggregates and protect organisms from proteostatic stress. In metazoans, the AAA(+) chaperone Skd3 in the mitochondrial intermembrane space (IMS) is critical for human health and efficiently refolds aggregated proteins, but its underlying mechanism i...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171807/ https://www.ncbi.nlm.nih.gov/pubmed/37163603 http://dx.doi.org/10.1126/sciadv.adf5336 |