Maternal Administration of the CNS-Selective Sobetirome Prodrug Sob-AM2 Exerts Thyromimetic Effects in Murine MCT8-Deficient Fetuses

BACKGROUND: Monocarboxylate transporter 8 (MCT8) deficiency is a rare X-linked disease where patients exhibit peripheral hyperthyroidism and cerebral hypothyroidism, which results in severe neurological impairments. These brain defects arise from a lack of thyroid hormones (TH) during critical stage...

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Detalles Bibliográficos
Autores principales: Valcárcel-Hernández, Víctor, Guillén-Yunta, Marina, Scanlan, Thomas S., Bárez-López, Soledad, Guadaño-Ferraz, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2023
Materias:
Thyroid Economy: Regulation, Cell Biology, and Thyroid Hormone Metabolism and Action
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171952/
https://www.ncbi.nlm.nih.gov/pubmed/36792926
http://dx.doi.org/10.1089/thy.2022.0612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171952/
https://www.ncbi.nlm.nih.gov/pubmed/36792926
http://dx.doi.org/10.1089/thy.2022.0612

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