Ligand and G-protein selectivity in the κ-opioid receptor

The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not only pain but also addiction and affective disorders(1). However, the development of KOR analgesics has been hindered by the associated hallucinogenic side effects(2). The initiation of KOR signalling requi...

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Detalles Bibliográficos
Autores principales: Han, Jianming, Zhang, Jingying, Nazarova, Antonina L., Bernhard, Sarah M., Krumm, Brian E., Zhao, Lei, Lam, Jordy Homing, Rangari, Vipin A., Majumdar, Susruta, Nichols, David E., Katritch, Vsevolod, Yuan, Peng, Fay, Jonathan F., Che, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172140/
https://www.ncbi.nlm.nih.gov/pubmed/37138078
http://dx.doi.org/10.1038/s41586-023-06030-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172140/
https://www.ncbi.nlm.nih.gov/pubmed/37138078
http://dx.doi.org/10.1038/s41586-023-06030-7

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