Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies that includes steatosis, steatohepatitis (NASH) and fibrosis and is strongly associated with insulin resistance and type 2 diabetes. Changes in mitochondrial function are implicated in the pathogenesis of NAFLD, particula...

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Detalles Bibliográficos
Autores principales: Undamatla, R., Fagunloye, O. G., Chen, J., Edmunds, L. R., Murali, A., Mills, A., Xie, B., Pangburn, M. M., Sipula, I., Gibson, G., St. Croix, C., Jurczak, M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172344/
https://www.ncbi.nlm.nih.gov/pubmed/37165006
http://dx.doi.org/10.1038/s41598-023-34710-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172344/
https://www.ncbi.nlm.nih.gov/pubmed/37165006
http://dx.doi.org/10.1038/s41598-023-34710-x

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