Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel

F508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation. The F508del defect can be targeted with pharmacological correctors, such as VX-809 and VX-445, that stabilize C...

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Detalles Bibliográficos
Autores principales: Renda, Mario, Barreca, Marilia, Borrelli, Anna, Spanò, Virginia, Montalbano, Alessandra, Raimondi, Maria Valeria, Bivacqua, Roberta, Musante, Ilaria, Scudieri, Paolo, Guidone, Daniela, Buccirossi, Martina, Genovese, Michele, Venturini, Arianna, Bandiera, Tiziano, Barraja, Paola, Galietta, Luis J. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172366/
https://www.ncbi.nlm.nih.gov/pubmed/37165082
http://dx.doi.org/10.1038/s41598-023-34440-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172366/
https://www.ncbi.nlm.nih.gov/pubmed/37165082
http://dx.doi.org/10.1038/s41598-023-34440-0

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