Polypyrimidine tract binding protein knockdown reverses depression-like behaviors and cognition impairment in mice with lesioned cholinergic neurons

BACKGROUND AND OBJECTIVES: Depression is a common comorbidity of dementia and may be a risk factor for dementia. Accumulating evidence has suggested that the cholinergic system plays a central role in dementia and depression, and the loss of cholinergic neurons is associated with memory decline in a...

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Detalles Bibliográficos
Autores principales: Zhou, Yiying, Zhang, Ke, Wang, Fangmin, Chen, Jiali, Chen, Shanshan, Wu, Manqing, Lai, Miaojun, Zhang, Yisheng, Zhou, Wenhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172502/
https://www.ncbi.nlm.nih.gov/pubmed/37181622
http://dx.doi.org/10.3389/fnagi.2023.1174341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172502/
https://www.ncbi.nlm.nih.gov/pubmed/37181622
http://dx.doi.org/10.3389/fnagi.2023.1174341

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