Z-flipon variants reveal the many roles of Z-DNA and Z-RNA in health and disease

Identifying roles for Z-DNA remains challenging given their dynamic nature. Here, we perform genome-wide interrogation with the DNABERT transformer algorithm trained on experimentally identified Z-DNA forming sequences (Z-flipons). The algorithm yields large performance enhancements (F1 = 0.83) over...

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Detalles Bibliográficos
Autores principales: Umerenkov, Dmitry, Herbert, Alan, Konovalov, Dmitrii, Danilova, Anna, Beknazarov, Nazar, Kokh, Vladimir, Fedorov, Aleksandr, Poptsova, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172764/
https://www.ncbi.nlm.nih.gov/pubmed/37164635
http://dx.doi.org/10.26508/lsa.202301962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172764/
https://www.ncbi.nlm.nih.gov/pubmed/37164635
http://dx.doi.org/10.26508/lsa.202301962

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