Cargando…

Z-flipon variants reveal the many roles of Z-DNA and Z-RNA in health and disease

Identifying roles for Z-DNA remains challenging given their dynamic nature. Here, we perform genome-wide interrogation with the DNABERT transformer algorithm trained on experimentally identified Z-DNA forming sequences (Z-flipons). The algorithm yields large performance enhancements (F1 = 0.83) over...

Descripción completa

Detalles Bibliográficos
Autores principales:	Umerenkov, Dmitry, Herbert, Alan, Konovalov, Dmitrii, Danilova, Anna, Beknazarov, Nazar, Kokh, Vladimir, Fedorov, Aleksandr, Poptsova, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172764/ https://www.ncbi.nlm.nih.gov/pubmed/37164635 http://dx.doi.org/10.26508/lsa.202301962

Ejemplares similares

Z-RNA and the Flipside of the SARS Nsp13 Helicase: Is There a Role for Flipons in Coronavirus-Induced Pathology?
por: Herbert, Alan, et al.
Publicado: (2022)

Deep learning approach for predicting functional Z-DNA regions using omics data
por: Beknazarov, Nazar, et al.
Publicado: (2020)

Conserved microRNAs and Flipons Shape Gene Expression during Development by Altering Promoter Conformations
por: Herbert, Alan, et al.
Publicado: (2023)

Special Issue: A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA
por: Herbert, Alan, et al.
Publicado: (2021)

Z-DNA and Z-RNA in human disease
por: Herbert, Alan
Publicado: (2019)

To “Z” or not to “Z”: Z-RNA, self-recognition, and the MDA5 helicase
por: Herbert, Alan
Publicado: (2021)

ALU non-B-DNA conformations, flipons, binary codes and evolution
por: Herbert, Alan
Publicado: (2020)

The Simple Biology of Flipons and Condensates Enhances the Evolution of Complexity
por: Herbert, Alan
Publicado: (2021)

Structure and Formation of Z-DNA and Z-RNA
por: Krall, Jeffrey B., et al.
Publicado: (2023)

Investigation of $H_{SUSY}\to Z Z, Z Z^{*}\to 4 leptons$
por: Kinnunen, Ritva
Publicado: (1997)

Z Z and $Z_\gamma$ at LEP2 and interpretations
por: Arcelli, S
Publicado: (2002)

TEST: A Z, A&Z, A<Z, A°Z, A Z, A±Z, AµZ End test. Analysis of soft tissue injuries associated with distal radius fractures
por: Ogawa, Takeshi, et al.
Publicado: (2013)

Unveiling the pathway to Z-DNA in the protein-induced B–Z transition
por: Kim, Sook Ho, et al.
Publicado: (2018)

The Sarcomeric Z-Disc and Z-Discopathies
por: Knöll, Ralph, et al.
Publicado: (2011)

Search for a Z' at the Z resonance
por: Adriani, O, et al.
Publicado: (1993)

Compositeness of $Z^{0}$, Z' at the LHC
por: Medcalf, T
Publicado: (1990)

Search for a Z' at the Z resonance
por: Riemann, S
Publicado: (1993)

Thermodynamic Model for B-Z Transition of DNA Induced by Z-DNA Binding Proteins
por: Lee, Ae-Ree, et al.
Publicado: (2018)

Flipons and small RNAs accentuate the asymmetries of pervasive transcription by the reset and sequence-specific microcoding of promoter conformation
por: Herbert, Alan
Publicado: (2023)

The Intransitive Logic of Directed Cycles and Flipons Enhances the Evolution of Molecular Computers by Augmenting the Kolmogorov Complexity of Genomes
por: Herbert, Alan
Publicado: (2023)

Sequence-dependent cost for Z-form shapes the torsion-driven B–Z transition via close interplay of Z-DNA and DNA bubble
por: Kim, Sook Ho, et al.
Publicado: (2021)

S/Z
por: Barthes, Roland
Publicado: (1980)

S/Z
por: Barthes, Roland
Publicado: (1970)

Z
Publicado: (1824)

Z
por: Gressner, Axel M., et al.
Publicado: (2012)

Searching for New Z-DNA/Z-RNA Binding Proteins Based on Structural Similarity to Experimentally Validated Zα Domain
por: Bartas, Martin, et al.
Publicado: (2022)

Equivalence of the Z$_{4}$ and the Z$_{2}$ x Z$_{2}$ lattice gauge theories
por: Grosse, Harald, et al.
Publicado: (1981)

Z-DNA enhances immunotherapy by triggering death of inflammatory cancer-associated fibroblasts
por: Herbert, Alan, et al.
Publicado: (2022)

Mono a Mano: ZBP1’s Love–Hate Relationship with the Kissing Virus
por: Herbert, Alan, et al.
Publicado: (2022)

The structures of non-CG-repeat Z-DNAs co-crystallized with the Z-DNA-binding domain, hZα(ADAR1)
por: Ha, Sung Chul, et al.
Publicado: (2009)

Human genomic Z-DNA segments probed by the Zα domain of ADAR1
por: Li, Heng, et al.
Publicado: (2009)

Alleviation of allergic conjunctivitis by (±)5(6)-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid in mice
por: Nagata, Nanae, et al.
Publicado: (2023)

Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ
por: de Rosa, Matteo, et al.
Publicado: (2013)

Studying Z-DNA and B- to Z-DNA transitions using a cytosine analogue FRET-pair
por: Dumat, Blaise, et al.
Publicado: (2016)

Ti-Catalyzed Cross-Cyclomagnesiation of 1,2-Dienes in the Total Z,Z,Z-Stereoselective Synthesis of Natural Acetogenin–Chatenaytrienin-1
por: D’yakonov, Vladimir A., et al.
Publicado: (2019)

"Z.Z." das ist die Zwischenzeit : ein Protokoll
por: Drach, Albert, 1902-
Publicado: (2005)

Comment on "Z - Z mixing in extended gauge theories"
por: Foot, R, et al.
Publicado: (1991)

Search for H --> Z$^{*}$Z$^{*}$ --> 4 leptons at LHC
por: Della Negra, Michel, et al.
Publicado: (1990)

$Z\gamma^{*}$ and $Z/\gamma^{*}ee$ at LEP2
por: Pieri, L
Publicado: (2002)

Uczniowie z Kluczborka jedli lunch z noblistami
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_5evqfekmg2o1i2p4gcc5mkq1lc