Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1

OBJECTIVES: In head and neck squamous cell carcinoma (HNSCC), tumors negative for Human Papillomavirus (HPV) remain a difficult to treat entity and the morbidity of current multimodal treatment is high. Radiotherapy in combination with molecular targeting could represent suitable, less toxic treatme...

Descripción completa

Detalles Bibliográficos
Autores principales: Oetting, Agnes, Christiansen, Sabrina, Gatzemeier, Fruzsina, Köcher, Sabrina, Bußmann, Lara, Böttcher, Arne, Stölzel, Katharina, Hoffmann, Anna Sophie, Struve, Nina, Kriegs, Malte, Petersen, Cordula, Betz, Christian, Rothkamm, Kai, Zech, Henrike Barbara, Rieckmann, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Special Issue on Personalized Radiation Oncology; Edited by Daniel Zips, Pierre Blanchard
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172863/
https://www.ncbi.nlm.nih.gov/pubmed/37180052
http://dx.doi.org/10.1016/j.ctro.2023.100630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172863/
https://www.ncbi.nlm.nih.gov/pubmed/37180052
http://dx.doi.org/10.1016/j.ctro.2023.100630

Ejemplares similares