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Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1

OBJECTIVES: In head and neck squamous cell carcinoma (HNSCC), tumors negative for Human Papillomavirus (HPV) remain a difficult to treat entity and the morbidity of current multimodal treatment is high. Radiotherapy in combination with molecular targeting could represent suitable, less toxic treatme...

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Detalles Bibliográficos
Autores principales:	Oetting, Agnes, Christiansen, Sabrina, Gatzemeier, Fruzsina, Köcher, Sabrina, Bußmann, Lara, Böttcher, Arne, Stölzel, Katharina, Hoffmann, Anna Sophie, Struve, Nina, Kriegs, Malte, Petersen, Cordula, Betz, Christian, Rothkamm, Kai, Zech, Henrike Barbara, Rieckmann, Thorsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Special Issue on Personalized Radiation Oncology; Edited by Daniel Zips, Pierre Blanchard
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172863/ https://www.ncbi.nlm.nih.gov/pubmed/37180052 http://dx.doi.org/10.1016/j.ctro.2023.100630

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