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Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones

Clonal hematopoiesis (CH) represents clonal expansion of mutated hematopoietic stem cells detectable in the peripheral blood or bone marrow through next generation sequencing. The current prevailing model posits that CH mutations detected in the peripheral blood mirror bone marrow mutations with clo...

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Detalles Bibliográficos
Autores principales: Osman, Afaf E. G., Mencia-Trinchant, Nuria, Saygin, Caner, Moma, Luke, Kim, Aelin, Housman, Genevieve, Pozsgai, Matthew, Sinha, Eti, Chandra, Pooja, Hassane, Duane C., Sboner, Andrea, Sangani, Kishan, DiNardi, Nick, Johnson, Christopher, Wallace, Sara S., Jabri, Bana, Luu, Hue, Guzman, Monica L., Desai, Pinkal, Godley, Lucy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172868/
https://www.ncbi.nlm.nih.gov/pubmed/36453641
http://dx.doi.org/10.1182/bloodadvances.2022008521