Rapid generation of a mouse model for evaluating on-target normal tissue toxicity of human CAR-T cells using replication-defective recombinant adenovirus

INTRODUCTION: The on-target off-tumor toxicity of chimeric antigen receptor-engineered T cells (CAR-T) might lead to fatal side effects in cancer patients, which remains as a major obstacle to the clinical application of CAR-T immunotherapy. The off-tumor on-target normal tissue toxicity of CAR-T ce...

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Detalles Bibliográficos
Autores principales: Liao, Qibin, Liu, Zhuoqun, Zhu, Cuisong, He, Huan, Feng, Meiqi, Jiang, Lang, Ding, Xiangqing, Sun, Rongxun, Zhang, Xiaoyan, Xu, Jianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173189/
https://www.ncbi.nlm.nih.gov/pubmed/35995414
http://dx.doi.org/10.1016/j.jare.2022.08.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173189/
https://www.ncbi.nlm.nih.gov/pubmed/35995414
http://dx.doi.org/10.1016/j.jare.2022.08.008

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