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Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice

BACKGROUND: Current influenza vaccines deliver satisfactory results in young people but are less effective in the elderly. Development of vaccines for an ever-increasing aging population has been an arduous challenge due to immunosenescence that impairs the immune response in the aged, both quantita...

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Detalles Bibliográficos
Autores principales: Park, Bo Ryoung, Bommireddy, Ramireddy, Chung, David Hyunjung, Kim, Ki-Hye, Subbiah, Jeeva, Jung, Yu-Jin, Bhatnagar, Noopur, Pack, Christopher D., Ramachandiran, Sampath, Reddy, Shaker J.C., Selvaraj, Periasamy, Kang, Sang-Moo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173218/
https://www.ncbi.nlm.nih.gov/pubmed/37170231
http://dx.doi.org/10.1186/s12979-023-00344-w