Engineered dual affinity protein fragments to bind collagen and capture growth factors

Collagen type I lacks affinity for growth factors (GFs) and yet it is clinically used to deliver bone morphogenic protein 2 (BMP-2), a potent osteogenic growth factor. To mitigate this lack of affinity, supra-physiological concentrations of BMP-2 are loaded in collagen sponges leading to uncontrolle...

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Detalles Bibliográficos
Autores principales: Sarrigiannidis, Stylianos O., Dobre, Oana, Navarro, Alexandre Rodrigo, Dalby, Matthew J., Gonzalez-Garcia, Cristina, Salmeron-Sanchez, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173277/
https://www.ncbi.nlm.nih.gov/pubmed/37179535
http://dx.doi.org/10.1016/j.mtbio.2023.100641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173277/
https://www.ncbi.nlm.nih.gov/pubmed/37179535
http://dx.doi.org/10.1016/j.mtbio.2023.100641

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