Synthetic miR-21 decoy circularized by tRNA splicing mechanism inhibited tumorigenesis in glioblastoma in vitro and in vivo models

Glioblastoma multiforme (GBM) is the deadliest primary central nervous system tumor. miRNAs (miRs), a class of non-coding RNAs, are considered pivotal post-transcriptional regulators of cell signaling pathways. miR-21 is a reliable oncogene that promotes tumorigenesis of cancer cells. We first perfo...

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Detalles Bibliográficos
Autores principales: Bayat, Hadi, Pourgholami, Mohammad Hossein, Rahmani, Saeid, Pournajaf, Safura, Mowla, Seyed Javad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173299/
https://www.ncbi.nlm.nih.gov/pubmed/37181451
http://dx.doi.org/10.1016/j.omtn.2023.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173299/
https://www.ncbi.nlm.nih.gov/pubmed/37181451
http://dx.doi.org/10.1016/j.omtn.2023.04.001

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