Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases

The COVID-19 pandemic reveals the urgent need to develop new therapeutics targeting the SARS-CoV-2 replication machinery. The first antiviral drugs were nucleoside analogues targeting RdRp and protease inhibitors active on nsp5 Mpro. In addition to these common antiviral targets, SARS-CoV-2 codes fo...

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Detalles Bibliográficos
Autores principales: Hausdorff, Marcel, Delpal, Adrien, Barelier, Sarah, Nicollet, Laura, Canard, Bruno, Touret, Franck, Colmant, Agathe, Coutard, Bruno, Vasseur, Jean-Jacques, Decroly, Etienne, Debart, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173359/
https://www.ncbi.nlm.nih.gov/pubmed/37192550
http://dx.doi.org/10.1016/j.ejmech.2023.115474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173359/
https://www.ncbi.nlm.nih.gov/pubmed/37192550
http://dx.doi.org/10.1016/j.ejmech.2023.115474

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