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Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases

The COVID-19 pandemic reveals the urgent need to develop new therapeutics targeting the SARS-CoV-2 replication machinery. The first antiviral drugs were nucleoside analogues targeting RdRp and protease inhibitors active on nsp5 Mpro. In addition to these common antiviral targets, SARS-CoV-2 codes fo...

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Detalles Bibliográficos
Autores principales:	Hausdorff, Marcel, Delpal, Adrien, Barelier, Sarah, Nicollet, Laura, Canard, Bruno, Touret, Franck, Colmant, Agathe, Coutard, Bruno, Vasseur, Jean-Jacques, Decroly, Etienne, Debart, Françoise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Masson SAS. 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173359/ https://www.ncbi.nlm.nih.gov/pubmed/37192550 http://dx.doi.org/10.1016/j.ejmech.2023.115474

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