Evaluation of Pathogenicity and Structural Alterations for the Mutations Identified in the Conserved Region of the C-Terminal Kinase Domain of Human-Ribosomal S6 Kinase 1

[Image: see text] Human-ribosomal s6 kinase 1 (h-RSK1) is an effector kinase of the Ras/MAPK signaling pathway, which is involved in the regulation of the cell cycle, proliferation, and survival. RSKs comprise two functionally distinct kinase domains at the N-terminal (NTKD) and C-terminal (CTKD) se...

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Detalles Bibliográficos
Autores principales: Chikhale, Vaishnvee, Goswami, Nabajyoti, Khan, Mudassar Ali, Borah, Probodh, Varma, Ashok K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173430/
https://www.ncbi.nlm.nih.gov/pubmed/37179615
http://dx.doi.org/10.1021/acsomega.3c00722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173430/
https://www.ncbi.nlm.nih.gov/pubmed/37179615
http://dx.doi.org/10.1021/acsomega.3c00722

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