Mathematical modeling identifies LAG3 and HAVCR2 as biomarkers of T cell exhaustion in melanoma

Cytotoxic T lymphocytes (CTLs) control tumors via lysis of antigen-presenting targets or through secretion of cytokines such as interferon-γ (IFNG), which inhibit tumor cell proliferation. Improved understanding of CTL interactions within solid tumors will aid the development of immunotherapeutic st...

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Detalles Bibliográficos
Autores principales: Beck, Richard J., Sloot, Sander, Matsushita, Hirokazu, Kakimi, Kazuhiro, Beltman, Joost B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173735/
https://www.ncbi.nlm.nih.gov/pubmed/37182110
http://dx.doi.org/10.1016/j.isci.2023.106666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173735/
https://www.ncbi.nlm.nih.gov/pubmed/37182110
http://dx.doi.org/10.1016/j.isci.2023.106666

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