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Conditional deletion of LRRC8A in the brain reduces stroke damage independently of swelling-activated glutamate release
The ubiquitous volume-regulated anion channels (VRACs) facilitate cell volume control and contribute to many other physiological processes. Treatment with non-specific VRAC blockers or brain-specific deletion of the essential VRAC subunit LRRC8A is highly protective in rodent models of stroke. Here,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173736/ https://www.ncbi.nlm.nih.gov/pubmed/37182109 http://dx.doi.org/10.1016/j.isci.2023.106669 |