Conditional deletion of LRRC8A in the brain reduces stroke damage independently of swelling-activated glutamate release

The ubiquitous volume-regulated anion channels (VRACs) facilitate cell volume control and contribute to many other physiological processes. Treatment with non-specific VRAC blockers or brain-specific deletion of the essential VRAC subunit LRRC8A is highly protective in rodent models of stroke. Here,...

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Detalles Bibliográficos
Autores principales: Balkaya, Mustafa, Dohare, Preeti, Chen, Sophie, Schober, Alexandra L., Fidaleo, Antonio M., Nalwalk, Julia W., Sah, Rajan, Mongin, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173736/
https://www.ncbi.nlm.nih.gov/pubmed/37182109
http://dx.doi.org/10.1016/j.isci.2023.106669

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