Mitochondrial Bcl-xL promotes brain synaptogenesis by controlling non-lethal caspase activation

Non-lethal caspase activation (NLCA) has been linked to neurodevelopmental processes. However, how neurons control NLCA remains elusive. Here, we focused on Bcl-xL, a Bcl-2 homolog regulating caspase activation through the mitochondria. We generated a mouse model, referred to as ER-xL, in which Bcl-...

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Detalles Bibliográficos
Autores principales: Nguyen, Trang Thi Minh, Gadet, Rudy, Lanfranchi, Marine, Lahaye, Romane A., Yandiev, Sozerko, Lohez, Olivier, Mikaelian, Ivan, Jabbour, Lea, Rimokh, Ruth, Courchet, Julien, Saudou, Frédéric, Popgeorgiev, Nikolay, Gillet, Germain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173740/
https://www.ncbi.nlm.nih.gov/pubmed/37182099
http://dx.doi.org/10.1016/j.isci.2023.106674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173740/
https://www.ncbi.nlm.nih.gov/pubmed/37182099
http://dx.doi.org/10.1016/j.isci.2023.106674

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