Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization

For the past 20 years, the majority of cell culture studies reported that increasing cholesterol level increases amyloid-β (Aβ) production. Conversely, other studies and genetic evidences support that cellular cholesterol loss leads to Aβ generation. As a highly controversial issue in Alzheimer’s di...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yue, Zhang, Wenbin, Guo, Xiaorou, Zhang, Ying, Wu, Junfeng, Zu, Hengbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173783/
https://www.ncbi.nlm.nih.gov/pubmed/37011864
http://dx.doi.org/10.1016/j.jlr.2023.100367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173783/
https://www.ncbi.nlm.nih.gov/pubmed/37011864
http://dx.doi.org/10.1016/j.jlr.2023.100367

Ejemplares similares