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Amount and Distribution of Intracranial Calcification in Symptomatic and Asymptomatic Primary Familial Brain Calcification

BACKGROUND AND OBJECTIVES: In clinical practice, it can be difficult to differentiate between intracranial calcifications related to primary familial brain calcification (PFBC) or aging. Also, little is known about the consequences of the amount of intracranial calcifications in patients with PFBC....

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Autores principales: Golüke, Nienke M.S., Meijer, Enrico, van Maren, Emiel A., de Jonghe, Annemarieke, Emmelot-Vonk, Mariëlle H., van Valen, Evelien, de Jong, Pim A., Koek, Huiberdina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173887/
https://www.ncbi.nlm.nih.gov/pubmed/37179845
http://dx.doi.org/10.1212/CPJ.0000000000200163
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author Golüke, Nienke M.S.
Meijer, Enrico
van Maren, Emiel A.
de Jonghe, Annemarieke
Emmelot-Vonk, Mariëlle H.
van Valen, Evelien
de Jong, Pim A.
Koek, Huiberdina L.
author_facet Golüke, Nienke M.S.
Meijer, Enrico
van Maren, Emiel A.
de Jonghe, Annemarieke
Emmelot-Vonk, Mariëlle H.
van Valen, Evelien
de Jong, Pim A.
Koek, Huiberdina L.
author_sort Golüke, Nienke M.S.
collection PubMed
description BACKGROUND AND OBJECTIVES: In clinical practice, it can be difficult to differentiate between intracranial calcifications related to primary familial brain calcification (PFBC) or aging. Also, little is known about the consequences of the amount of intracranial calcifications in patients with PFBC. Therefore, we aimed to compare the amount and distribution of intracranial calcifications in persons with PFBC with controls and between asymptomatic and symptomatic PFBC cases. METHODS: This was a case-control study including patients with PFBC and controls. Controls received a CT of the brain because of a trauma and had at least some basal ganglia calcification. The Nicolas score and volume of calcification were used to quantify intracranial calcifications on the CT scans. Receiver operating characteristic curves were obtained to calculate optimal cutoff points to discriminate between cases and controls. Mann-Whitney U tests and logistic regression, adjusted for age and sex, were used to compare the amount of calcification. RESULTS: Twenty-eight cases (median age 65 years, 50.0% male) and 90 controls (median age 74 years, 46.1% male) were included. Calcification scores were higher in cases (median volume: 4.91 cm(3) against 0.03 cm(3), p < 0.001, median Nicolas score: 26.5 against 2.0, p < 0.001) than controls. Calcifications were also more diffusely distributed in cases. To differentiate between cases and controls, optimal cutoff points were ≥0.2 cm(3) for the calcification volume and ≥6.0 for the Nicolas score. Calcification was higher for symptomatic than asymptomatic cases (calcification volume: 13.62 cm(3) against 1.61 cm(3), p = 0.01, Nicolas score: 39.0 against 15.5, p = 0.02). After adjustment for age and sex, the Nicolas score remained significantly higher in symptomatic patients, and the calcification volume did not. DISCUSSION: Patients with PFBC had more severe intracranial calcifications, and these calcifications were more diffusely distributed through the brain compared with controls. Symptomatic patients with PFBC might have more intracranial calcifications than asymptomatic persons.
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spelling pubmed-101738872023-05-12 Amount and Distribution of Intracranial Calcification in Symptomatic and Asymptomatic Primary Familial Brain Calcification Golüke, Nienke M.S. Meijer, Enrico van Maren, Emiel A. de Jonghe, Annemarieke Emmelot-Vonk, Mariëlle H. van Valen, Evelien de Jong, Pim A. Koek, Huiberdina L. Neurol Clin Pract Research Article BACKGROUND AND OBJECTIVES: In clinical practice, it can be difficult to differentiate between intracranial calcifications related to primary familial brain calcification (PFBC) or aging. Also, little is known about the consequences of the amount of intracranial calcifications in patients with PFBC. Therefore, we aimed to compare the amount and distribution of intracranial calcifications in persons with PFBC with controls and between asymptomatic and symptomatic PFBC cases. METHODS: This was a case-control study including patients with PFBC and controls. Controls received a CT of the brain because of a trauma and had at least some basal ganglia calcification. The Nicolas score and volume of calcification were used to quantify intracranial calcifications on the CT scans. Receiver operating characteristic curves were obtained to calculate optimal cutoff points to discriminate between cases and controls. Mann-Whitney U tests and logistic regression, adjusted for age and sex, were used to compare the amount of calcification. RESULTS: Twenty-eight cases (median age 65 years, 50.0% male) and 90 controls (median age 74 years, 46.1% male) were included. Calcification scores were higher in cases (median volume: 4.91 cm(3) against 0.03 cm(3), p < 0.001, median Nicolas score: 26.5 against 2.0, p < 0.001) than controls. Calcifications were also more diffusely distributed in cases. To differentiate between cases and controls, optimal cutoff points were ≥0.2 cm(3) for the calcification volume and ≥6.0 for the Nicolas score. Calcification was higher for symptomatic than asymptomatic cases (calcification volume: 13.62 cm(3) against 1.61 cm(3), p = 0.01, Nicolas score: 39.0 against 15.5, p = 0.02). After adjustment for age and sex, the Nicolas score remained significantly higher in symptomatic patients, and the calcification volume did not. DISCUSSION: Patients with PFBC had more severe intracranial calcifications, and these calcifications were more diffusely distributed through the brain compared with controls. Symptomatic patients with PFBC might have more intracranial calcifications than asymptomatic persons. Lippincott Williams & Wilkins 2023-08 2023-05-05 /pmc/articles/PMC10173887/ /pubmed/37179845 http://dx.doi.org/10.1212/CPJ.0000000000200163 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Research Article
Golüke, Nienke M.S.
Meijer, Enrico
van Maren, Emiel A.
de Jonghe, Annemarieke
Emmelot-Vonk, Mariëlle H.
van Valen, Evelien
de Jong, Pim A.
Koek, Huiberdina L.
Amount and Distribution of Intracranial Calcification in Symptomatic and Asymptomatic Primary Familial Brain Calcification
title Amount and Distribution of Intracranial Calcification in Symptomatic and Asymptomatic Primary Familial Brain Calcification
title_full Amount and Distribution of Intracranial Calcification in Symptomatic and Asymptomatic Primary Familial Brain Calcification
title_fullStr Amount and Distribution of Intracranial Calcification in Symptomatic and Asymptomatic Primary Familial Brain Calcification
title_full_unstemmed Amount and Distribution of Intracranial Calcification in Symptomatic and Asymptomatic Primary Familial Brain Calcification
title_short Amount and Distribution of Intracranial Calcification in Symptomatic and Asymptomatic Primary Familial Brain Calcification
title_sort amount and distribution of intracranial calcification in symptomatic and asymptomatic primary familial brain calcification
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173887/
https://www.ncbi.nlm.nih.gov/pubmed/37179845
http://dx.doi.org/10.1212/CPJ.0000000000200163
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