AR-A014418 regulates intronic polyadenylation and transcription of PD-L1 through inhibiting CDK12 and CDK13 in tumor cells

BACKGROUND: Immune checkpoint molecules, especially programmed death 1 (PD-1) and its ligand, programmed death ligand 1 (PD-L1), protect tumor cells from T cell-mediated killing. Immune checkpoint inhibitors, designed to restore the antitumor immunosurveillance, have exhibited significant clinical b...

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Detalles Bibliográficos
Autores principales: Zhang, Ganggang, Lan, Bin, Zhang, Xin, Lin, Mengyao, Liu, Yi, Chen, Junsong, Guo, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174041/
https://www.ncbi.nlm.nih.gov/pubmed/37164450
http://dx.doi.org/10.1136/jitc-2022-006483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174041/
https://www.ncbi.nlm.nih.gov/pubmed/37164450
http://dx.doi.org/10.1136/jitc-2022-006483

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