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Increased death and exhaustion of CD69(high) T cells and NK cells are associated with PD-1 antibody application in the in vitro co-culture system
BACKGROUND: The application of PD-1 monoclonal antibody (mAb) helps to treat non-small cell lung cancer, but acquired resistance has emerged in clinical practice. We tested the hypothesis that acquired resistance of anti-PD-1 immunotherapy is linked to death and exhaustion of activated T and NK cell...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
PeerJ Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174060/ https://www.ncbi.nlm.nih.gov/pubmed/37180581 http://dx.doi.org/10.7717/peerj.15374 |