High baseline tumor burden‐associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2‐STAT3‐PD‐L1 pathway

BACKGROUND: Several clinical studies have uncovered a negative correlation between baseline tumor burden and the efficacy of immune checkpoint inhibitor (ICI) treatment. This study aimed to uncover the specific mechanisms underlying the difference in sensitivity to ICI treatment between tumors with...

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Detalles Bibliográficos
Autores principales: Wen, Zhaowei, Sun, Huiying, Zhang, Zhihua, Zheng, Yannan, Zheng, Siting, Bin, Jianping, Liao, Yulin, Shi, Min, Zhou, Rui, Liao, Wangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174084/
https://www.ncbi.nlm.nih.gov/pubmed/37031362
http://dx.doi.org/10.1002/cac2.12420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174084/
https://www.ncbi.nlm.nih.gov/pubmed/37031362
http://dx.doi.org/10.1002/cac2.12420

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