Predicting anti-cancer drug combination responses with a temporal cell state network model

Cancer chemotherapy combines multiple drugs, but predicting the effects of drug combinations on cancer cell proliferation remains challenging, even for simple in vitro systems. We hypothesized that by combining knowledge of single drug dose responses and cell state transition network dynamics, we co...

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Detalles Bibliográficos
Autores principales: Sarmah, Deepraj, Meredith, Wesley O., Weber, Ian K., Price, Madison R., Birtwistle, Marc R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174488/
https://www.ncbi.nlm.nih.gov/pubmed/37126527
http://dx.doi.org/10.1371/journal.pcbi.1011082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174488/
https://www.ncbi.nlm.nih.gov/pubmed/37126527
http://dx.doi.org/10.1371/journal.pcbi.1011082

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