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Mapping the motion and structure of flexible proteins from cryo-EM data
A deep learning algorithm maps out the continuous conformational changes of flexible protein molecules from single-particle cryo-electron microscopy images, allowing the visualization of the conformational landscape of a protein with improved resolution of its moving parts.
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174731/ https://www.ncbi.nlm.nih.gov/pubmed/37169930 http://dx.doi.org/10.1038/s41592-023-01883-2 |
| _version_ | 1785040097739014144 |
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| collection | PubMed |
| description | A deep learning algorithm maps out the continuous conformational changes of flexible protein molecules from single-particle cryo-electron microscopy images, allowing the visualization of the conformational landscape of a protein with improved resolution of its moving parts. |
| format | Online Article Text |
| id | pubmed-10174731 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group US |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-101747312023-05-14 Mapping the motion and structure of flexible proteins from cryo-EM data Nat Methods Research Briefing A deep learning algorithm maps out the continuous conformational changes of flexible protein molecules from single-particle cryo-electron microscopy images, allowing the visualization of the conformational landscape of a protein with improved resolution of its moving parts. Nature Publishing Group US 2023-05-12 2023 /pmc/articles/PMC10174731/ /pubmed/37169930 http://dx.doi.org/10.1038/s41592-023-01883-2 Text en © Springer Nature America, Inc. 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Research Briefing Mapping the motion and structure of flexible proteins from cryo-EM data |
| title | Mapping the motion and structure of flexible proteins from cryo-EM data |
| title_full | Mapping the motion and structure of flexible proteins from cryo-EM data |
| title_fullStr | Mapping the motion and structure of flexible proteins from cryo-EM data |
| title_full_unstemmed | Mapping the motion and structure of flexible proteins from cryo-EM data |
| title_short | Mapping the motion and structure of flexible proteins from cryo-EM data |
| title_sort | mapping the motion and structure of flexible proteins from cryo-em data |
| topic | Research Briefing |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10174731/ https://www.ncbi.nlm.nih.gov/pubmed/37169930 http://dx.doi.org/10.1038/s41592-023-01883-2 |