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Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures
Starting with the clinical application of two vaccines in 2020, mRNA therapeutics are currently being investigated for a variety of applications. Removing immunogenic uncapped mRNA from transcribed mRNA is critical in mRNA research and clinical applications. Commonly used capping methods provide max...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175277/ https://www.ncbi.nlm.nih.gov/pubmed/37169757 http://dx.doi.org/10.1038/s41467-023-38244-8 |