Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures

Starting with the clinical application of two vaccines in 2020, mRNA therapeutics are currently being investigated for a variety of applications. Removing immunogenic uncapped mRNA from transcribed mRNA is critical in mRNA research and clinical applications. Commonly used capping methods provide max...

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Detalles Bibliográficos
Autores principales: Inagaki, Masahito, Abe, Naoko, Li, Zhenmin, Nakashima, Yuko, Acharyya, Susit, Ogawa, Kazuya, Kawaguchi, Daisuke, Hiraoka, Haruka, Banno, Ayaka, Meng, Zheyu, Tada, Mizuki, Ishida, Tatsuma, Lyu, Pingxue, Kokubo, Kengo, Murase, Hirotaka, Hashiya, Fumitaka, Kimura, Yasuaki, Uchida, Satoshi, Abe, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175277/
https://www.ncbi.nlm.nih.gov/pubmed/37169757
http://dx.doi.org/10.1038/s41467-023-38244-8

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