The impact of metabolic stressors on mitochondrial homeostasis in a renal epithelial cell model of methylmalonic aciduria

Methylmalonic aciduria (MMA-uria) is caused by deficiency of the mitochondrial enzyme methylmalonyl-CoA mutase (MUT). MUT deficiency hampers energy generation from specific amino acids, odd-chain fatty acids and cholesterol. Chronic kidney disease (CKD) is a well-known long-term complication. We exp...

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Detalles Bibliográficos
Autores principales: Schumann, Anke, Brutsche, Marion, Havermans, Monique, Grünert, Sarah C., Kölker, Stefan, Groß, Olaf, Hannibal, Luciana, Spiekerkoetter, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175303/
https://www.ncbi.nlm.nih.gov/pubmed/37169781
http://dx.doi.org/10.1038/s41598-023-34373-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175303/
https://www.ncbi.nlm.nih.gov/pubmed/37169781
http://dx.doi.org/10.1038/s41598-023-34373-8

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