3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib

Osimertinib sensitive and resistant NSCLC NCI-H1975 clones are used to model osimertinib acquired resistance in humanized and non-humanized mice and delineate potential resistance mechanisms. No new EGFR mutations or loss of the EGFR T790M mutation are found in resistant clones. Resistant tumors gro...

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Detalles Bibliográficos
Autores principales: Meraz, Ismail M., Majidi, Mourad, Fang, Bingliang, Meng, Feng, Gao, Lihui, Shao, RuPing, Song, Renduo, Li, Feng, Lissanu, Yonathan, Chen, Huiqin, Ha, Min Jin, Wang, Qi, Wang, Jing, Shpall, Elizabeth, Jung, Sung Yun, Haderk, Franziska, Gui, Philippe, Riess, Jonathan Wesley, Olivas, Victor, Bivona, Trever G., Roth, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175489/
https://www.ncbi.nlm.nih.gov/pubmed/37169941
http://dx.doi.org/10.1038/s42003-023-04889-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175489/
https://www.ncbi.nlm.nih.gov/pubmed/37169941
http://dx.doi.org/10.1038/s42003-023-04889-w

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